MersV1, Main, Exploration, bibRecord, 002461

Genomic structure and expression analyses of the PYGM gene in the thoroughbred horse.

Identifieur interne : 002461 ( Main/Exploration ); précédent : 002460; suivant : 002462

Genomic structure and expression analyses of the PYGM gene in the thoroughbred horse.

Auteurs : Gyu-Hwi Nam [Corée du Sud] ; Kung Ahn ; Jin-Han Bae ; Kyudong Han ; Chong-Eon Lee ; Kyung-Do Park ; Sang-Hak Lee ; Byung-Wook Cho ; Heui-Soo Kim

Source :

Zoological science [ 0289-0003 ] ; 2011.

RBID : pubmed:21466345

Descripteurs français

KwdFr :
- Animaux, Equus caballus (génétique), Equus caballus (métabolisme), Expression des gènes, Génomique, Muscles squelettiques (métabolisme), Myophosphorylase (génétique), Pedigree, RT-PCR, Séquences répétées dispersées, Éléments transposables d'ADN.
MESH :
- génétique : Equus caballus, Myophosphorylase.
- métabolisme : Equus caballus, Muscles squelettiques.
- Animaux, Expression des gènes, Génomique, Pedigree, RT-PCR, Séquences répétées dispersées, Éléments transposables d'ADN.

English descriptors

KwdEn :
- Animals, DNA Transposable Elements, Gene Expression, Genomics, Glycogen Phosphorylase, Muscle Form (genetics), Horses (genetics), Horses (metabolism), Interspersed Repetitive Sequences, Muscle, Skeletal (metabolism), Pedigree, Reverse Transcriptase Polymerase Chain Reaction.
MESH :
- chemical , genetics : Glycogen Phosphorylase, Muscle Form.
- chemical : DNA Transposable Elements.
- genetics : Horses.
- metabolism : Horses, Muscle, Skeletal.
- Animals, Gene Expression, Genomics, Interspersed Repetitive Sequences, Pedigree, Reverse Transcriptase Polymerase Chain Reaction.

Abstract

Muscle glycogen Phosphorylase (PYGM) has been shown to catalyze the degradation of glycogen to glucose-1-phosphate. The PYGM gene can contribute to providing energy to the body by disassembling the glycogen in muscle. Here, we analyzed the genomic structure and expression of the PYGM gene in the thoroughbred horse. The PYGM gene, containing several transposable elements (MIRs, LINEs, and MERs), was highly conserved in mammalian genomes. In order to understand the expression of the horse PYGM gene, we performed quantitative RT-PCR using 11 thoroughbred horse tissue samples. The horse PYGM gene was broadly expressed in all tissues tested. In particular, the highest expression of the horse PYGM gene was observed in skeletal muscle tissue relative to the other tissues. Interestingly, the horse PYGM gene contains fewer mobile elements than its human ortholog, resulting in an increase in the structural stability of the PYGM gene sequence. This study provides insights into the genomic structure of the horse PYGM gene that may be useful in future studies of its association with exercise capability.

DOI: 10.2108/zsj.28.276
PubMed: 21466345

Affiliations:

Corée du Sud

Le document en format XML

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<term>Horses (metabolism)</term>
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<front><div type="abstract" xml:lang="en">Muscle glycogen Phosphorylase (PYGM) has been shown to catalyze the degradation of glycogen to glucose-1-phosphate. The PYGM gene can contribute to providing energy to the body by disassembling the glycogen in muscle. Here, we analyzed the genomic structure and expression of the PYGM gene in the thoroughbred horse. The PYGM gene, containing several transposable elements (MIRs, LINEs, and MERs), was highly conserved in mammalian genomes. In order to understand the expression of the horse PYGM gene, we performed quantitative RT-PCR using 11 thoroughbred horse tissue samples. The horse PYGM gene was broadly expressed in all tissues tested. In particular, the highest expression of the horse PYGM gene was observed in skeletal muscle tissue relative to the other tissues. Interestingly, the horse PYGM gene contains fewer mobile elements than its human ortholog, resulting in an increase in the structural stability of the PYGM gene sequence. This study provides insights into the genomic structure of the horse PYGM gene that may be useful in future studies of its association with exercise capability.</div>
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Genomic structure and expression analyses of the PYGM gene in the thoroughbred horse.

Genomic structure and expression analyses of the PYGM gene in the thoroughbred horse.

Source :

Descripteurs français

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri

Pour générer des pages wiki

	Serveur d'exploration MERS
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